Seven of the 10 states with the lowest prime-age EPOP are in the South: Prime-age EPOP by state and for the U.S.

State EPOP
United States  78.2%
Oklahoma 75.9%
California 75.6%
Kentucky 75.3%
Alaska 75.3%
Arkansas  75.2%
Louisiana 74.6%
Alabama 74.4%
New Mexico 73.0%
Mississippi 73.0%
West Virginia  72.7%

Source: EPI analysis of 2017–2021 Current Population Survey from the U.S. Census Bureau.   

View the underlying data on epi.org.